2-(Methylsulfonamido)phenylacetonitrile → HCID 20848391, compound

HRID 656271Notes

Reaction equation

HRID 656271 reaction equation
[CH3:1][S:2]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[CH2:12][C:13]#[N:14])(=[O:4])=[O:3]>CO.[Pd]>[CH3:1][S:2]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[CH2:12][CH2:13][NH2:14])(=[O:4])=[O:3]

Participants

4

Reactant 1

HCID 691184052-(Methylsulfonamido)phenylacetonitrile

Product 1

HCID 20848391HCID 20848391, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

(2-Methanesulfonylaminophenyl)acetonitrile (300 mg) was mixed with 10% palladium/carbon (catalytic amount) in methanol (20 ml) and the mixture was stirred under hydrogen gas atmospheres for 48 hours. After confirming the completion of the reaction using TLC, the resulting mixture was filtered through celite and the filtrate was concentrated under reduced pressure. The following procedure was carried out using the concentrate which was not purified.

Workup

  1. filtrationthe resulting mixture was filtered through celite
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. concentrationconcentrate which
  4. customwas not purified

Sources & evidence

ORD record
ord-234744b45fc34bb790657b2e28e616eb
Source dataset
uspto-grants-2011_12
Patent number
US08071650B2

Reaction notes

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