HCID 19003109, compound → HCID 45087085, compound

HRID 656299Notes

Reaction equation

HRID 656299 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([C:10]#[N:11])[N:7]([CH3:9])[CH:8]=1)([O-])=O>CO.[Pd]>[C:10]([C:6]1[N:7]([CH3:9])[CH:8]=[C:4]([NH2:1])[CH:5]=1)#[N:11]

Participants

4

Reactant 1

HCID 19003109HCID 19003109, compound

Product 1

HCID 45087085HCID 45087085, compoundYield 77.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Compound 22-5 (500 mg) and 10% palladium/carbon (50 mg) were poured into the reactor and dissolved in methanol (10 ml), and then reacted under hydrogen gas atmosphere for 2 hours. After confirming the completion of the reaction, the resulting mixture was filtered through celite, and the filtrate was concentrated under reduced pressure and purified by column-chromatography (ethyl acetate/hexane=3/1) to yield the compound 22-6 (310 mg, 77.4%).

Workup

  1. customreacted under hydrogen gas atmosphere for 2 hours
  2. customthe completion of the reaction
  3. filtrationthe resulting mixture was filtered through celite
  4. concentrationthe filtrate was concentrated under reduced pressure
  5. custompurified by column-chromatography (ethyl acetate/hexane=3/1)

Sources & evidence

ORD record
ord-a63bc3aed1ea4d46b0b68ae38a89468d
Source dataset
uspto-grants-2011_12
Patent number
US08071650B2

Reaction notes

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