Dimethylformamide → HCID 69229591, compound

Participants

Reaction Steps

Sodium hydride (18 mg) was suspended in dimethylformamide, and to the suspension was added a solution of N-t-butyloxycarbonyl-p-aminobenzylamine (150 mg) and methylaminosulfamoylchloride (97 mg) in dimethylformamide while the temperature was controlled to 0° C., followed by stirring at room temperature for 3 hours. The reaction solution was evaporated under reduced pressure, and the residue was diluted with ethyl acetate (70 ml), washed with saturated aqueous sodium bicarbonate solution, water and saturated saline, and then evaporated under reduced pressrure. The obtained residue was purified by column-chromatography (hexane/ethyl acetate=5/1) to yield the compound 35-1a (170 mg, 79%).

Provenance & Evidence