HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-Cyclohexyl-1-[(2-nitrophenyl)sulfonyl]piperidine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Nitrobenzenesulfonyl chloride | HCID 15540 | — |
| Reactant | HCID 18071645 | HCID 18071645 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | N-Cyclohexyl-1-[(2-nitrophenyl)sulfonyl]piperidine-3-carboxamide | HCID 11675603 | 60.1% |
Reaction Steps
To a solution of 2-nitrobenzene-1-sulfonyl chloride (12.3 mg) and N-cyclohexylpiperidine-3-carboxamide (TFA salt, 18 mg) from Step 2 in 0.2 mL acetonitrile was added triethylamine (19.3 μL). The reaction mixture was stirred at RT for 2 hours and directly purified by HPLC to give 13.2 mg of desired product. LCMS: m/z 396.1 (M+H)+; 813.3 (2M+Na)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08071624B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-f49a806fe3024f128cb4c161d4e9d832 |
| Source note | uspto-grants-2011_12 |