HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 178427912, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Chloro-2-methylbenzenesulfonyl chloride | HCID 522734 | — |
| Reactant | HCID 178479694 | HCID 178479694 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 178427912 | HCID 178427912 | 36.2% |
Reaction Steps
A mixture of (3S)-N-(cyclopropylmethyl)-N-(trans-4-hydroxycyclohexyl)piperidine-3-carboxamide hydrochloride (10 mg, 0.03 mmol), 3-chloro-2-methylbenzenesulfonyl chloride (7.1 mg, 0.03 mmol), triethylamine (11 μL, 0.08 mmol) in acetonitrile (0.2 mL) was stirred at r.t. for 1 hour, then purified with flash column. 5.1 mg (yield: 34%) final product was obtained. LCMS: m/z 468.9 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08071624B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-a31408777ad94398bff9783be22f2fd4 |
| Source note | uspto-grants-2011_12 |