6-Aminohexanoic Acid → HCID 57605522, compound

Participants

Reaction Steps

To a solution of 6-Aminohexanoic acid (0.158.g, 1.2 mmole) dissolved in 0.1M NaHCO3 (2.0 mL) was added the NHS ester 2 (0.68 g, 1.3 mmole) in 4 mL of anhydrous THF. The reaction mixture was stirred at RT for 2 hr. The solvent was completely evaporated and the dried solid residue obtained was dissolved in CH3OH/CH2Cl2 mixture and purified by silica gel column chromatography using 10% CH3OH/CH2Cl2 and obtained 3 as a white solid on evaporation the solvent. Yield: 0.5 g (77%).

Provenance & Evidence