Water → 1',3'-dihydrospiro[imidazolidine-4,2'-indene]-2,5-dione

Participants

Reaction Conditions

Reaction Steps

A stirred mixture of 2-indanone (3.0 g, 22.6 mmol), sodium cyanide (3.3 g, 67.3 mmol), and ammonium carbonate (22 g, 228 mol) in H2O (50 mL) and EtOH (50 mL) was heated to 70° C. for 3 h, then allowed to cool to ambient temperature. The precipitate was collected by filtration and washed with H2O (5×100 mL). Drying in vacuo afforded the title compound. MS: m/z=202 (M+1).

Provenance & Evidence