(+/-)-3-Methyl-5'-nitro-spiro[imidazolidine-4,2'-indane]-2,5-dione → (+/-)-3' Methyl-2',5'-dioxo-6,8-dihydrospiro[cyclopenta[g]quinoline-7,4'-imidazolidine]-2-carbaldehyde
Reaction equation
[CH3:1][N:2]1[C@@:6]2([CH2:20][C:9]3[CH:10]=[C:11]4[C:16](=[CH:17][C:8]=3[CH2:7]2)[N:15]=[C:14]([CH:18]=[O:19])[CH:13]=[CH:12]4)[C:5](=[O:21])[NH:4][C:3]1=[O:22].CN1C2(CC3C(=CC=C([N+]([O-])=O)C=3)C2)C(=O)NC1=O>>[CH3:1][N:2]1[C:6]2([CH2:20][C:9]3[CH:10]=[C:11]4[C:16](=[CH:17][C:8]=3[CH2:7]2)[N:15]=[C:14]([CH:18]=[O:19])[CH:13]=[CH:12]4)[C:5](=[O:21])[NH:4][C:3]1=[O:22]Participants
3
Reactant 2
Product 1
Procedure
Essentially following the procedures described for Intermediate 13, but using (±)-5′-amino-3-methyl-spiro[imidazolidine-4,2′-indane]-2,5-dione (described in Intermediate 7) in place of (R)-5′-amino-3-methyl-spiro[imidazolidine-4,2′-indane]-2,5-dione, the title compound is prepared.
Sources & evidence
- ORD record
- ord-3581edc866744a0cb24e027fed96f841
- Source dataset
- uspto-grants-2011_12
- Patent number
- US08071771B2
Reaction notes
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