Trifluoroacetic acid → HCID 68577477, compound

Participants

Reaction Steps

1 mmol of tert-butyl 6-aminomethyl-2-benzyl-2,7-diazaspiro[4.5]decane-7-carboxylate is dissolved in 2 ml of dichloromethane and the solution is admixed with 2 ml of trifluoroacetic acid. The reaction solution is stirred at room temperature until conversion is complete and then is poured into saturated aqueous sodium hydrogen carbonate solution. The phases are separated and the aqueous phase is extracted with dichloromethane. The combined organic phases are washed with brine, dried over sodium sulphate and evaporated. From the residue the title compound is identified by means of flash chromatography (SiO2 60 F) on the basis of the Rf value.

Provenance & Evidence