Triethylamine → HCID 86629996, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 10 mmol of tert-butyl 2-benzyl-6-hydroxymethyl-2,7-diazaspiro[4.5]decane-7-carboxylate in 30 ml of dichloromethane is admixed at 0° C. with 15 mmol of triethylamine, followed by 11 mmol of methanesulphonyl chloride. The reaction mixture is stirred at 0° C. for an hour and then at room temperature for an hour. The reaction mixture is poured into saturated aqueous sodium hydrogen carbonate solution and extracted with dichloromethane. The combined organic extracts are washed with brine, dried with sodium sulphate and evaporated. From the residue the title compound is identified by means of flash chromatography (SiO2 60 F) on the basis of the Rf value.

Provenance & Evidence