Hydrogen Peroxide → HCID 68577163, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 5 mmol of tert-butyl 2-benzyl-6-methylene-2,7-diazaspiro[4.5]decane-7-carboxylate in 60 ml of tetrahydrofuran is admixed at 0° C. with 10.6 mmol of 9-borabicyclo[3.3.1]nonane (0.5M in tetrahydrofuran). The reaction solution is stirred at 60° C. for 15 hours and then cooled to room temperature. The solution is admixed with 50 ml each of 3M sodium hydroxide solution and 30% hydrogen peroxide. The reaction mixture is stirred at room temperature for 2 hours. Subsequently the phases are separated and the aqueous phase is saturated with potassium carbonate and extracted with ethyl acetate (3×). The combined organic phases are dried over sodium sulphate and evaporated. From the residue the title compound is identified by means of flash chromatography (SiO2 60 F) on the basis of the Rf value.

Provenance & Evidence