Dimethylformamide → HCID 15979314, compound

Participants

Reaction Conditions

Reaction Steps

An apparatus purified by baking is charged under argon with 1.160 mmol of 3′,4′,6,7-tetrahydro-2′H,5H-spiro[imidazo[1,5-a]pyridine-8,1′-naphthalen]-7′-yl trifluoromethanesulphonate together with 2.320 mmol zinc(II) cyanide in 15 ml of degassed N,N-dimethylformamide. 0.093 mmol of tetrakis(triphenylphosphine)palladium is added and the reaction mixture is stirred at 120° C. for 20 hours. The reaction mixture is cooled and poured into 100 ml of ice-water. It is extracted with ethyl acetate (3×). The combined organic phases are dried over magnesium sulphate and evaporated. From the residue the title compound is obtained by means of flash chromatography (SiO2 60F) as a white solid. Rf=0.165 (dichloromethane-2M ammonia in EtOH=95:5); Rt=5.64.

Provenance & Evidence