Phosphorus oxychloride → HCID 57468507, compound

Participants

Reaction Steps

A solution of 10 mmol of 5-(2-bromo-5-methoxyphenoxymethyl)-5,6,7,8-tetrahydroquinazolin-5-ol and 20 mmol of phosphorus oxychloride in 20 ml of pyridine is heated at reflux for 0.5-1 hour. The mixture is poured onto ice and extracted with tert-butyl methyl ether. The combined organic extracts are washed with brine, dried with sodium sulphate and evaporated. From the residue the title compound is identified by means of flash chromatography (SiO2 60F) on the bias of the Rf value.

Provenance & Evidence