HCID 66915648, compound → HCID 66915570, compound

HRID 656492Notes

Reaction equation

HRID 656492 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]2[C:9]3([CH2:18][O:19][C:5]=2[CH:4]=1)[CH2:14][CH2:13][CH2:12][N:11]1[CH:15]=[N:16][CH2:17][CH:10]31>C1(C)C=CC=CC=1.[O-2].[O-2].[Mn+4]>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]2[C:9]3([CH2:18][O:19][C:5]=2[CH:4]=1)[CH2:14][CH2:13][CH2:12][N:11]1[CH:15]=[N:16][CH:17]=[C:10]31

Participants

4

Reactant 1

HCID 66915648HCID 66915648, compound

Product 1

HCID 66915570HCID 66915570, compound

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 1140TolueneSolvent

Procedure

A mixture of 1.9 mmol of 6-methoxy-1′,6′,7′,8a′-tetrahydro-5′H-spiro[1-benzofuran-3,8′-imidazo[1,5-a]pyridine] and 3 g of manganese-dioxide in 50 ml of toluene is heated to reflux for 1.5 hours. The reaction mixture is cooled to room temperature, the solid is removed by filtration over Hyflo and the filtrate is evaporated. From the residue the title compound is identified by means of flash chromatography (SiO2 60F) on the basis of the Rf value.

Workup

  1. temperatureis heated
  2. temperatureto reflux for 1.5 hours
  3. customthe solid is removed by filtration over Hyflo
  4. customthe filtrate is evaporated

Sources & evidence

ORD record
ord-f987487544fa4511ad8f32f032c3f674
Source dataset
uspto-grants-2011_12
Patent number
US08071774B2

Reaction notes

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