化工社化工社 化学情報印刷レポート · 研究参考用
Tramadol → Desmetramadol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tramadol | HCID 33741 | — |
| 反応物 | (-)-(S,S)-trans-Tramadol | HCID 667511 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Desmetramadol | HCID 9838803 | — |
反応手順
To prepare the (+) enantiomer of the title compound, the reaction was run under the same conditions except that (+)-tramadol as the free base was used instead of the (−)-tramadol to yield 2.8 g of the (+) enantiomer of O-desmethyl tramadol (mp. 242°-3° C.) [α]D25=+32.2 (C=1, EtOH).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | USRE039221E1 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-74561ba7ee694134bb00b8692de7b1b8 |
| 出典メモ | uspto-grants-2006_08 |