Tert-butyl 3-oxopyrrolidine-1-carboxylate → 2,2-Dimethyl-1-(5-(pyrrolidin-3-ylamino)-1H-indazol-1-yl)propan-1-one
Reaction equation
O=[C:2]1[CH2:6][CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1.C(O)(=O)/C=C\C(O)=O.[NH2:22][C:23]1[CH:24]=[C:25]2[C:29](=[CH:30][CH:31]=1)[N:28]([C:32](=[O:37])[C:33]([CH3:36])([CH3:35])[CH3:34])[N:27]=[CH:26]2>>[CH3:34][C:33]([CH3:36])([CH3:35])[C:32]([N:28]1[C:29]2[C:25](=[CH:24][C:23]([NH:22][CH:2]3[CH2:6][CH2:5][NH:4][CH2:3]3)=[CH:31][CH:30]=2)[CH:26]=[N:27]1)=[O:37]Participants
3
Procedure
Reaction of tert-butyl 3-oxopyrrolidine-1-carboxylate and 1-(5-amino-1H-indazol-1-yl)-2,2-dimethylpropan-1-one maleate salt using the method of Example 3 followed by deprotection using the method of Example 4 afforded the title compound.
Sources & evidence
- ORD record
- ord-2a4dbf1c664e48e299a05793d274d8cf
- Source dataset
- uspto-grants-2011_12
- Patent number
- US08071779B2
Reaction notes
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