5-Bromoisoquinoline → HCID 59799791, compound

HRID 656538Notes

Reaction equation

[NH2:1][C@H:2]1[CH2:6][CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1.Br[C:15]1[CH:24]=[CH:23][CH:22]=[C:21]2[C:16]=1[CH:17]=[CH:18][N:19]=[CH:20]2>>[NH:4]1[CH2:5][CH2:6][C@H:2]([NH:1][C:15]2[C:16]3[CH:17]=[CH:18][N:19]=[CH:20][C:21]=3[CH:22]=[CH:23][CH:24]=2)[CH2:3]1

Participants

Reactant 2

HCID 7364875-Bromoisoquinoline

HCID 854071tert-butyl (3S)-3-aminopyrrolidine-1-carboxylate

Product 1

HCID 59799791HCID 59799791, compound

Procedure

Reaction of (S)-tert-butyl 3-aminopyrrolidine-1-carboxylate and 5-bromoisoquinoline using the method of Example 16 followed by deprotection using the method of Example 4 afforded the title compound.

Sources & evidence

ORD record: ord-b3ed8964b7b945c68cfe6ae0531eaa6d
Source dataset: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08071779B2

Reaction notes

Loading…