HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Piperidinone, 1-(phenylmethyl)- → N5-(1-Benzylpiperidin-3-yl)-1H-indazole-3,5-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Piperidinone, 1-(phenylmethyl)- | HCID 96650 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | tert-butyl 3,5-diamino-1H-indazole-1-carboxylate | HCID 23571038 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N5-(1-Benzylpiperidin-3-yl)-1H-indazole-3,5-diamine | HCID 57446051 | — |
Reaction Steps
Reaction of tert-butyl 3,5-diamino-1H-indazole-1-carboxylate with 1-benzylpiperidin-3-one using the method of Example 8, with the modification that sodium cyanoborohydride was used as the reductant and methanol was used as the solvent, followed by deprotection using the method of Example 4 afforded the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08071779B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-26dd9c6a25a341e2a3f49a00fa6539a2 |
| Source note | uspto-grants-2011_12 |