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HRID65660

反应详情

EQUATION

反应方程式

HRID 65660 的结构方程式

REACTANTS

反应物

2
结构：CN=C=O
HCID12228

Methyl isocyanate

C2H3NO

结构：Cc1cn([C@H]2C[C@H](N)[C@@H](CO)O2)c(=O)[nH]c1=O
HCID108074

1-(3-Amino-2,3-dideoxypentofuranosyl)-4-hydroxy-5-methylpyrimidin-2(1H)-one

C10H15N3O4

PRODUCTS

生成物

1
结构：CNC(=O)N[C@H]1C[C@H](n2cc(C)c(=O)[nH]c2=O)O[C@@H]1CO
HCID54528106

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

To a solution of 7 (0.48 g, 2.00 mmol) in 15 ml of methanol, methyl isocyanate (0.13 g, 2.20 mmol) was added slowly. The solution was stirred at 0° for 1 h, during which period, white crystals precipitated out. The product was collected by filtration, washed with cooled methanol, and dried, to give 0.54 g (90%). The compound softened at 114° and effervesced at 120°; TLC: Rf 0.38. Anal. (C12H18N4O5) C, H, N.

WORKUP

后处理

  1. customprecipitated out
  2. filtrationThe product was collected by filtration
  3. washwashed with cooled methanol
  4. customdried
  5. customto give 0.54 g (90%)
  6. customsoftened at 114°
  7. customeffervesced at 120°