反应详情

A mixture of tetrahydro-3,5-bis[(4-methoxyphenyl)-methylene-4H-thiopyran-4-one (4.9 g, 14 mmole) and 2-amino-2-thiazoline (1.8 g, 17.6 mmole) in acetone (300 ml) is heated at reflux temperature overnight. The precipitate (4.7 g) collected is a mixture of starting ketone and intermediate aminol (4-[(4,5-dihydro-2-thiazolyl)amino]tetrahydro-3,5-bis[(4-methoxyphenyl)methylene]thiopyran-4-ol) in a ratio of 4:6.

1. temperatureis heated
2. temperatureat reflux temperature overnight
3. customThe precipitate (4.7 g) collected
4. additiona mixture of starting ketone and intermediate aminol (4-[(4,5-dihydro-2-thiazolyl)amino]tetrahydro-3,5-bis[(4-methoxyphenyl)methylene]thiopyran-4-ol) in a ratio of 4:6