反应详情

To a solution of N-cyclopropyl-2-mercapto-acetamide (6.65 g, 50.68 mmol) in MeOH (100 ml), is added sodium methoxide solution (25% wt. in MeOH)(11.59 ml, 50.68 mmol). The resulting solution is stirred at room temperature for 10 minutes, and then treated with 2,5-dichloro-6-methoxy-4-methyl-nicotinonitrile (10.0 g, 46.07 mmol). The reaction vessel is sealed and heated at 100° C. for 2 hours. The reaction mixture is cooled to room temperature and poured over 500 ml of cold water. A thick white precipitate is formed. The mixture is stirred at 0° C. for 10 minutes, then the solid is collected by filtration. The fluffy white solid (title compound) is placed in the vacuum oven at 60° C. to dry overnight (7.74 g, 54%). Mass (m/z): 312.0 (M++1).

1. customThe reaction vessel is sealed
2. temperatureheated at 100° C. for 2 hours
3. temperatureThe reaction mixture is cooled to room temperature
4. customA thick white precipitate is formed
5. stirringThe mixture is stirred at 0° C. for 10 minutes
6. filtrationthe solid is collected by filtration
7. customis placed in the vacuum oven at 60° C.
8. customto dry overnight (7.74 g, 54%)