反应详情

To a stirred suspension of 4-[(4,5-dihydro-2-thiazolyl)-amino]tetrahydro-3,5-bis[(4-methylphenyl)methylene]thiopyran-4-ol (from Part A) (2.5 gm; 5.9 mmole) in dry toluene (120 ml), is added slowly a solution of titanium tetrachloride (0.56 gm; 3.0 mmole) in toluene (5.4 ml). The orange mixture is heated at reflux temperature for 1.5 hour. After it is cooled, the solid is pulverized and filtered.

1. temperatureThe orange mixture is heated
2. temperatureat reflux temperature for 1.5 hour
3. temperatureAfter it is cooled
4. filtrationfiltered