참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-Fluoronaphthalene | HCID 9450 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 3-(Dimethylamino)-1-(2-thienyl)-1-propanol | HCID 11586409 | — |
| 반응물 | Potassium (2S,3S)-3-carboxy-2,3-dihydroxypropanoate | HCID 23687508 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | N,N-dimethyl-3-(naphthyloxy)-3-(2-thienyl)propylamine D-tartrate | HCID 86625060 | — |
반응 단계
A mixture of N,N-dimethyl-3-hydroxy-3-(2-thienyl)propylamine (185 g, 1 mole), potassium hydroxide (112 g, 2 moles) and 1-fluoronaphthalene (146 g, 1 mole) in dimethylsulfoxide (1000 ml) is stirred at 110° C. for 2 hours. After cooling down to 20° C., the mixture is filtered, diluted with water (3 ), monopotassium D-tartrate (188 g, 1 mole) is added, and the mixture is stirred at 80° C. for 0.5 hour. After cooling down, the precipitated product is sucked off, washed with water and dried. Yield: 328 g (85%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08071791B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_12 |
|---|
| ORD ID | ord-a604ab954ddb4e9896b45ba704a0443d |
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| 출처 메모 | uspto-grants-2011_12 |
|---|
