Potassium Carbonate → [3-(4-Chloro-2-formyl-phenoxy)-4-methoxy-phenyl]-acetic acid ethyl ester

참여 물질

역할	이름	HCID	투입량
반응물	Potassium Carbonate	HCID 11430	—
반응물	5-Chloro-2-fluorobenzaldehyde	HCID 2773586	—
반응물	Ethyl 2-(3-hydroxy-4-methoxyphenyl)acetate	HCID 5324706	—
용매	1,4-Dioxane	HCID 31275	—
생성물	[3-(4-Chloro-2-formyl-phenoxy)-4-methoxy-phenyl]-acetic acid ethyl ester	HCID 58237578	—

반응 조건

온도	100 °C

반응 단계

(3-Hydroxy-4-methoxy-phenyl)-acetic acid ethyl ester (0.75 g, 4.8 mmol), 5-chloro-2-fluorobenzaldehyde (1.0 g, 4.8 mmol), and potassium carbonate (1.0 g, 7.5 mmol) were combined in 1,4-dioxane (30 mL) and heated to 100° C. for 3 days. After work-up, the crude material was purified by silica gel chromatography (0-20% EtOAc in hexanes) to give the title compound.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08071807B2
출처 데이터셋	uspto-grants-2011_12
ORD ID	ord-b2840495aa81404883459abaa84dd745
출처 메모	uspto-grants-2011_12