HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus tribromide → [3-(2-Bromomethyl-4-chloro-phenoxy)-4-methoxy-phenyl]-acetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus tribromide | HCID 24614 | — |
| Reactant | [3-(4-Chloro-2-hydroxymethyl-phenoxy)-4-methoxy-phenyl]acetic acid ethyl ester | HCID 58237450 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | [3-(2-Bromomethyl-4-chloro-phenoxy)-4-methoxy-phenyl]-acetic acid ethyl ester | HCID 58237456 | — |
Reaction Steps
To [3-(4-chloro-2-hydroxymethyl-phenoxy)-4-methoxy-phenyl]-acetic acid ethyl ester (0.9 g 2.6 mmol) in DME was added phosphorus tribromide (0.37 mL, 3.9 mmol), and the reaction was stirred for 3 hours at room temperature. The mixture was worked-up to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08071807B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-6df37c965867404d8cd259c17d994102 |
| Source note | uspto-grants-2011_12 |