Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | {3-[4-(4-Chloro-benzoylamino)-2-phenylsulfanylmethyl-phenoxy]-4-methoxy-phenyl}-acetic acid ethyl ester | HCID 58372825 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 44601068 | HCID 44601068 | — |
Reaction Steps
To {3-[4-(4-chloro-benzoylamino)-2-phenylsulfanylmethyl-phenoxy]-4-methoxy-phenyl}-acetic acid ethyl ester (0.9 mmol) was added lithium hydroxide (0.3 g), H2O (5 mL), and MeOH (20 mL). The reaction was stirred at 60° C., and then worked up and purified by preparative HPLC to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08071807B2 |
|---|
| Source dataset | uspto-grants-2011_12 |
|---|
| ORD ID | ord-0e059a2febbd43b48569bf3e58dec44e |
|---|
| Source note | uspto-grants-2011_12 |
|---|
