HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 656745Generated: October 26, 2026
Potassium Carbonate → [3-(4-Bromo-2-formyl-phenoxy)-4-methoxy-phenyl]acetic acid ethyl ester
https://huagongshe.com/reaction/656745
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Bromo-2-fluorobenzaldehyde | HCID 736327 | — |
| Reactant | Ethyl 2-(3-hydroxy-4-methoxyphenyl)acetate | HCID 5324706 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | [3-(4-Bromo-2-formyl-phenoxy)-4-methoxy-phenyl]acetic acid ethyl ester | HCID 58237615 | 48.2% |
Reaction Steps
(3-Hydroxy-4-methoxy-phenyl)-acetic acid ethyl ester (2.0 g, 9.5 mmol), 5-bromo-2-fluorobenzaldehyde (2.0 g, 9.5 mmol), and potassium carbonate (2.0 g, 14.3 mmol) were combined in 1,4-dioxane and heated to 90° C. overnight. After work-up, the crude material was purified by silica gel chromatography (0-25% EtOAc in hexanes) to give the desired product (1.8 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08071807B2 |
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| Source dataset | uspto-grants-2011_12 |
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| ORD ID | ord-c4d7e6b90e0a4705b1c643e762d88aff |
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| Source note | uspto-grants-2011_12 |
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