HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Propanethiol → [3-(4-Bromo-2-isopropylsulfanylmethyl-phenoxy)-4-methoxy-phenyl]-acetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Propanethiol | HCID 6364 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | [3-(4-Bromo-2-bromomethyl-phenoxy)-4-methoxy-phenyl]acetic acid ethyl ester | HCID 58237498 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | [3-(4-Bromo-2-isopropylsulfanylmethyl-phenoxy)-4-methoxy-phenyl]-acetic acid ethyl ester | HCID 58372820 | — |
Reaction Steps
To [3-(4-bromo-2-bromomethyl-phenoxy)-4-methoxy-phenyl]-acetic acid ethyl ester and 2-propanethiol in 1,4-dioxane was added sodium hydride (60% in mineral oil), and the reaction was stirred for 1 hour at room temperature. After work-up, the crude material was purified by silica gel chromatography (0-20% EtOAc in hexanes) to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08071807B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-ae91e225504340eda08b33183f36768f |
| Source note | uspto-grants-2011_12 |