Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium Chloride | HCID 433294 | — |
| Reactant | 2-(3-Benzyloxy-5-chloro-phenyl)-malonic acid dimethyl ester | HCID 58372778 | — |
| Solvent | (Methanesulfinyl)methane--water (1/1) | HCID 23503278 | — |
| Product | HCID 58372832 | HCID 58372832 | — |
Reaction Steps
A mixture of 2-(3-benzyloxy-5-chloro-phenyl)-malonic acid dimethyl ester (21 g, 60.2 mmol) and lithium chloride (3.06 g, 72.2 mmol) in DMSO:H2O (10:1; 200 mL) was stirred at 150° C. for 5 hours. After cooling to room temperature, H2O (500 mL) was added, and the mixture was extracted with EtOAc:hexanes (1:10; 1.5 L total) to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08071807B2 |
|---|
| Source dataset | uspto-grants-2011_12 |
|---|
| ORD ID | ord-6ae15aab3dc9497980fbc108a0125117 |
|---|
| Source note | uspto-grants-2011_12 |
|---|
