HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 656778Generated: October 30, 2026
Benzyl Alcohol → (3-Benzyloxy-4-chloro-phenyl)-acetic acid
https://huagongshe.com/reaction/656778
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzyl Alcohol | HCID 244 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-(4-Chloro-3-fluorophenyl)acetic acid | HCID 3814954 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | (3-Benzyloxy-4-chloro-phenyl)-acetic acid | HCID 58149177 | — |
Reaction Steps
To 4-chloro-3-fluorophenylacetic acid (5 g, 26.5 mmol) and benzyl alcohol (5.5 mL, 53.0 mmol) in NMP (50 mL) at 0° C. was added sodium hydride (60% in mineral oil; 2.3 g, 58.3 mmol), and the reaction was then heated to 120° C. and stirred overnight. The mixture was acidified to pH 4 and extracted with EtOAc to give (3-benzyloxy-4-chloro-phenyl)-acetic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08071807B2 |
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| Source dataset | uspto-grants-2011_12 |
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| ORD ID | ord-f925dda70f604d1fa940ad5c833c0833 |
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| Source note | uspto-grants-2011_12 |
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