Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Isatin → (3Z)-3-diazo-1H-indol-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Isatin | HCID 7054 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | P-Toluenesulfonylhydrazide | HCID 15303 | — |
| 반응물 | Alumina | HCID 9989226 | — |
| 생성물 | (3Z)-3-diazo-1H-indol-2-one | HCID 136455454 | — |
반응 단계
Once the desired isatin has been obtained, the corresponding 3-diazoindol-2(3H)-one is prepared in accordance with known procedures. See, for example, J. M. Michowski, Tetrahedron Letters, 1773 (1967) and M. P. Cava, et al., J. Am. Chem. Soc., 80, 2257 (1958). The appropriate isatin compound is treated with p-toluenesulfonylhydrazine. The resulting hydrazone then is treated with a base such as aqueous sodium hydroxide or aluminum oxide to give the desired 3-diazoindol-2(3H)-one.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04128644 |
| 출처 데이터셋 | uspto-grants-1978_12 |
| ORD ID | ord-6b95a365086e4e3fa90b5593564ad1c0 |
| 출처 메모 | uspto-grants-1978_12 |