Phenyl isocyanate → HCID 135735619, compound

Participants

Reaction Steps

2.0 g (0.0093 mole) of 2-(hydroxymethyl)pyrazolo-[1,5-c]quinazolin-5(6H)-one prepared as described in Example 6B and 1.55 ml (≅1.7 g or 0.014 mole) of 98% phenylisocyanate are refluxed in 20 ml of dry pyridine under N2 for 1 hour. The crude product is poured onto 200 ml of ice-water layered with ethyl acetate (50 ml) and stirred for 30 minutes. The precipitates that form are filtered off, air-dried and taken up in dioxane (150 ml). The solution is filtered while hot and the clear filtrate concentrated down to a volume of 100 ml and cooled. The precipitates are filtered off and dried in vacuo at 85°. Yield 2.45 g, 78.8% crude yield.

Provenance & Evidence