Methylamine → HCID 57823927, compound

Participants

Reaction Steps

I-86 is prepared analogously except the starting material was 6-acetyl-5-cyclopropyl-2-(4-phenoxy-phenyl)-benzofuran-3-carboxylic acid methylamide. I-103 and I-104 can be prepared from A-2c by introduction of the p-fluorophenyl by Suzuki coupling with p-fluoro-phenol (see step 5 of example 3), Freidel-Crafts acylation, hydrolysis of the ethyl ester and coupling with methylamine and addition of methyl magnesium bromide as carried described in the current example.

Provenance & Evidence