反应详情

A mixture of 7-cyano-1-(2-propen-1-yl)quinolinium iodide (1.75 g, 5.4 mmol), potassium hydroxide (1.33 g, 23.76 mmol) and potassium ferricyanide (3.9 g, 11.9 mmol) in 50% 1,4-dioxane/water was stirred at rt for 2 h. Water (50 ml) was then added and the organic phase was extracted with 10% methanol/DCM (2×100 ml). The combined organic phases were washed with water (100 ml) then dried and evaporated. The residue was chromatographed on silica gel, eluting with 0-5% methanol-DCM to afford the desired compound (0.6 g, 55%).

1. extractionthe organic phase was extracted with 10% methanol/DCM (2×100 ml)
2. washThe combined organic phases were washed with water (100 ml)
3. customthen dried
4. customevaporated
5. customThe residue was chromatographed on silica gel
6. washeluting with 0-5% methanol-DCM