反应详情

A solution of 5-bromo-2,3-pyridinediamine (465 mg, 2.473 mmol) and glyoxylic acid monohydrate (284 mg, 3.09 mmol) in water (5 ml) was stirred at rt for 3 h and the resultant precipitate was filtered and washed with water (50 ml), MeOH (20 ml) and finally diethyl ether (20 ml) before drying in vacuo gave the desired product as a light brown solid (368 mg, 66%).

1. filtrationthe resultant precipitate was filtered
2. washwashed with water (50 ml), MeOH (20 ml) and finally diethyl ether (20 ml)
3. custombefore drying in vacuo