5-Bromopyridine-2,3-diamine → HCID 57815479, compound

HRID 656931Notes

Reaction equation

HRID 656931 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([NH2:9])[C:5]([NH2:8])=[N:6][CH:7]=1.O.[C:11](O)(=O)[CH:12]=[O:13]>O>[Br:1][C:2]1[CH:7]=[N:6][C:5]2[N:8]=[CH:11][C:12](=[O:13])[NH:9][C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 6911565-Bromopyridine-2,3-diamineHCID 15620607Glyoxylic acid, monohydrate

Product 1

HCID 57815479HCID 57815479, compoundYield 66%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 5-bromo-2,3-pyridinediamine (465 mg, 2.473 mmol) and glyoxylic acid monohydrate (284 mg, 3.09 mmol) in water (5 ml) was stirred at rt for 3 h and the resultant precipitate was filtered and washed with water (50 ml), MeOH (20 ml) and finally diethyl ether (20 ml) before drying in vacuo gave the desired product as a light brown solid (368 mg, 66%).

Workup

  1. filtrationthe resultant precipitate was filtered
  2. washwashed with water (50 ml), MeOH (20 ml) and finally diethyl ether (20 ml)
  3. custombefore drying in vacuo

Sources & evidence

ORD record
ord-7b75d598085549259a192167e3a83d42
Source dataset
uspto-grants-2011_12
Patent number
US08071592B2

Reaction notes

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