6,7-Dihydro-[1,4]dioxino[2,3-c]pyridazine-3-carbaldehyde → 1-(2-{4-[(6,7-dihydro[1,4]dioxino[2,3-c]pyridazin-3-ylmethyl)amino]-1-piperidinyl}ethyl)-5,7-difluoro-2(1H)-quinolinone Diformate

Participants

Reaction Steps

The title compound was prepared by the general method of Example 32(g) using 1-[2-(4-amino-1-piperidinyl)ethyl]-5,7-difluoro-2(1H)-quinolinone and 6,7-dihydro[1,4]dioxino[2,3-c]pyridazine-3-carbaldehyde to give the desired product directly as the diformate salt (34 mg; 15%).

Provenance & Evidence