Benzyl 2-[4-(tert-butoxycarbonylamino)piperidin-1-yl]ethylcarbamate → 1,1-Dimethylethyl N-[1-(2-aminoethyl)-4-piperidinyl]carbamate

Beteiligte Stoffe

Reaktionsschritte

A solution of 1,1-dimethylethyl {1-[2-({[(phenylmethyl)oxy]carbonyl}amino)ethyl]-4-piperidinyl}carbamate (8.2 g, 21.8 mmol) in ethanol (500 ml) was hydrogenated overnight over 10% palladium on charcoal (50% dispersion with water, 4.0 g). The mixture was filtered, evaporated, and azeotroped with chloroform to afford the title intermediate (5.4 g, 100%).

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