反应详情

A mixture of N-methyl-N'-(2-pyridyl)-formamidine (2.5 g, 0.0185 m), 2,4-dimethylphenylisocyanide (2.4 g, 0.0185 m), cuprous oxide (trace amount) and dry toluene (60 ml) was heated on a steam bath with occasional agitation for 4 hours. The reaction mixture was then cooled, filtered through "Hyflo" (diatomaceous earth) and alumina, and the toluene filtrate evaporated to dryness in vacuo to yield a viscous oil. The oil was triturated with 60°-80° petroleum ether to yield a white solid. Crystallisation of this solid from ether/60° -- 80° petroleum ether yielded the product, 5-(2,4-dimethylphenyl)-3-methyl-1-(2-pyridyl)-1,3,5-triazapenta-1,4-diene, (1.0 g) m.p. 100°.

1. temperaturewas heated on a steam bath with occasional agitation for 4 hours
2. temperatureThe reaction mixture was then cooled
3. filtrationfiltered through "Hyflo" (diatomaceous earth) and alumina
4. customthe toluene filtrate evaporated to dryness in vacuo
5. customto yield a viscous oil
6. customThe oil was triturated with 60°-80° petroleum ether
7. customto yield a white solid
8. customCrystallisation of this solid from ether/60°