Fumaric Acid → HCID 68816412, compound

HRID 656984Notes

Reaction equation

HRID 656984 reaction equation
[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]/[C:4]([OH:6])=[O:5].[N:9]1[C:14]2[O:15][CH2:16][CH2:17][O:18][C:13]=2[CH:12]=[C:11]([CH2:19][NH:20][CH:21]2[CH2:26][CH2:25][N:24]([CH2:27][CH2:28][N:29]3[C:38]4[C:33](=[CH:34][CH:35]=[C:36]([F:39])[CH:37]=4)[N:32]=[CH:31][C:30]3=[O:40])[CH2:23][CH2:22]2)[N:10]=1>CO.C(Cl)Cl>[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]/[C:4]([OH:6])=[O:5].[N:9]1[C:14]2[O:15][CH2:16][CH2:17][O:18][C:13]=2[CH:12]=[C:11]([CH2:19][NH:20][CH:21]2[CH2:26][CH2:25][N:24]([CH2:27][CH2:28][N:29]3[C:38]4[C:33](=[CH:34][CH:35]=[C:36]([F:39])[CH:37]=4)[N:32]=[CH:31][C:30]3=[O:40])[CH2:23][CH2:22]2)[N:10]=1

Participants

5

Reactant 2

HCID 444972Fumaric AcidHCID 57928001HCID 57928001, compound

Product 1

HCID 68816412HCID 68816412, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Procedure

Addition of one equivalent of 0.5M fumaric acid in MeOH (5.9 mL) to a solution of 1-(2-{4-[(6,7-dihydro[1,4]dioxino[2,3-c]pyridazin-3-ylmethyl)amino]-1-piperidinyl}ethyl)-7-fluoro-2(1H)-quinoxalinone (1.30 g, 2.95 mmol) in DCM, followed by evaporation, provided the fumarate salt of the title compound as an off-white solid (1.55 g).

Workup

  1. customfollowed by evaporation

Sources & evidence

ORD record
ord-9e7490865e0643459a07fc458349b58e
Source dataset
uspto-grants-2011_12
Patent number
US08071592B2

Reaction notes

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