反应详情

温度

100 °C

Methyl N-(4-fluoro-2-nitrophenyl)glycinate (40 g, 175 mmol) in water (2000 mL) was heated to 90° C. Sodium dithionite (243.8 g, 1401 mmol) was added in portions. The resulting mixture was heated at 100° C. for 2 h, then allowed to cool. The solid was filtered off, washed with water and dried to give the product (13.75, 47%). Concentration of the liquor by evaporation to ˜700 mL gave a further precipitate which was filtered off, washed and dried as before to give more product (1.90 g: total yield 15.65 g, 54%).

1. temperatureto cool
2. filtrationThe solid was filtered off
3. washwashed with water
4. customdried
5. customto give the product (13.75, 47%)
6. customConcentration of the liquor by evaporation to ˜700 mL
7. customgave a further precipitate which
8. filtrationwas filtered off
9. washwashed
10. customdried as before
11. customto give more product (1.90 g: total yield 15.65 g, 54%)