Fumaric Acid → HCID 68995130, compound

HRID 656992Notes

Reaction equation

[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]/[C:4]([OH:6])=[O:5].[N:9]1[C:14]2[O:15][CH2:16][CH2:17][O:18][C:13]=2[CH:12]=[C:11]([CH2:19][NH:20][CH:21]2[CH2:26][CH2:25][N:24]([CH2:27][CH2:28][N:29]3[C:34](=[O:35])[CH:33]=[N:32][C:31]4[CH:36]=[CH:37][C:38]([O:40][CH3:41])=[N:39][C:30]3=4)[CH2:23][CH2:22]2)[N:10]=1>>[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]/[C:4]([OH:6])=[O:5].[N:9]1[C:14]2[O:15][CH2:16][CH2:17][O:18][C:13]=2[CH:12]=[C:11]([CH2:19][NH:20][CH:21]2[CH2:22][CH2:23][N:24]([CH2:27][CH2:28][N:29]3[C:34](=[O:35])[CH:33]=[N:32][C:31]4[CH:36]=[CH:37][C:38]([O:40][CH3:41])=[N:39][C:30]3=4)[CH2:25][CH2:26]2)[N:10]=1

Participants

Reactant 2

HCID 444972Fumaric Acid

HCID 25030979HCID 25030979, compound

Product 1

HCID 68995130HCID 68995130, compound

Procedure

Addition of one equivalent of fumaric acid to a solution of 4-(2-{4-[(6,7-dihydro [1,4]dioxino[2,3-c]pyridazin-3-ylmethyl)amino]-1-piperidinyl}ethyl)-6-(methyloxy)pyrido[2,3-b]pyrazin-3(4H)-one, followed by evaporation, provided the title compound.

Workup

customfollowed by evaporation

Sources & evidence

ORD record: ord-48659327e0b34e3380b99d60ea23630a
Source dataset: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08071592B2

Reaction notes

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