反应详情

To a stirred solution of 7-(methyloxy)-1-(2-propen-1-yl)-2(1H)-quinolinone (4.14 g, 0.019 mol) in 1,4-dioxane (80 ml) and water (40 ml) under N2 was added sodium periodate (9.5 g; 0.044 mol) and osmium tetroxide (10 ml, 4% aqueous solution) and stirred overnight. The reaction was concentrated and partitioned in 20% MeOH/DCM (300 ml) and water (200 ml). The organic layer was dried over magnesium sulphate, filtered, and concentrated. The product was obtained after column chromatography (neat ethyl acetate) to yield g (71%) of the title compound as a green solid.

1. concentrationThe reaction was concentrated
2. custompartitioned in 20% MeOH/DCM (300 ml)
3. dry with materialThe organic layer was dried over magnesium sulphate
4. filtrationfiltered
5. concentrationconcentrated
6. customThe product was obtained after column chromatography (neat ethyl acetate)