Phenylmethyl [((3R,4R)-4-hydroxy-1-{2-[7-(methyloxy)-2-oxo-1(2H)-quinolinyl]ethyl}-3-pyrrolidinyl)methyl]carbamate → 1-{2-[(3R,4R)-3-(Aminomethyl)-4-hydroxy-1-pyrrolidinyl]ethyl}-7-(methyloxy)-2(1H)-quinolinone

Participants

Reaction Steps

To a solution of phenylmethyl [((3R,4R)-4-hydroxy-1-{2-[7-(methyloxy)-2-oxo-1(2H)-quinolinyl]ethyl}-3-pyrrolidinyl)methyl]carbamate (337 mg, 0.746 mmol) was added 20% Pd(OH)2/C, degassed and placed under 1 atm of H2 for 18 h. The reaction mixture was filtered through Celite and concentrated to obtain the title compound as a yellow oil (235 mg, 100%).

Provenance & Evidence