反应详情

A solution of 1-{2-[(3S,4S)-3-(aminomethyl)-4-hydroxy-1-pyrrolidinyl]ethyl}-7-fluoro-2(1H)-quinolinone (100 mg; 0.33 mmol) and 3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-6-carboxaldehyde (for a synthesis see WO2003087098, Example 31(e)) (60 mg, 0.33 mmol) in methanol (2 mL), DCM (4 mL) was stirred at room temperature overnight. Sodium triacetoxyborohydride (0.13 g; 0.6 mmol) was added and the mixture was stirred at room temperature for 1 hour. The reaction was evaporated and chromatographed on silica gel, eluting with 0-20% methanol-DCM-2% NH4OH to give an oil. The oil was treated with 1M HCl in Et2O to give the title compound (73 mg) as the dihydrochloride salt.

1. customThe reaction was evaporated
2. customchromatographed on silica gel
3. washeluting with 0-20% methanol-DCM-2% NH4OH
4. customto give an oil