反应详情

3-(Methyloxy)-6-({[4-(methyloxy)phenyl]methyl}oxy)pyrido[2,3-b]pyrazine (0.6 g, 2 mmol) was dissolved in acetonitrile (100 mL) and then ammonium cerium (IV) nitrate (1.09 g, 2 mmol) dissolved in water (50 mL) was added. The reaction was stirred at rt for 0.5 h and then 20% MeOH/DCM and water were added. The layers were separated and the aqueous was extracted with 20% MeOH/DCM twice more. The combined organic phases were dried, filtered and evaporated and the crude was purified by trituration with diethyl ether to afford the title compound (0.3 g, 85%).

1. additionwas added
2. customThe layers were separated
3. extractionthe aqueous was extracted with 20% MeOH/DCM twice more
4. customThe combined organic phases were dried
5. filtrationfiltered
6. customevaporated
7. customthe crude was purified by trituration with diethyl ether