HCID 86635350, compound → HCID 68995056, compound

Participants

Reaction Steps

A solution of phenylmethyl [((3S,4S)-4-hydroxy-1-{2-[6-(methyloxy)-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl]ethyl}-3-pyrrolidinyl)methyl]carbamate (1.0 g, 2.2 mmol) in methanol was treated with 10% Pd/C (0.44 g) and shaken under 15 psi at room temperature for 2 hours. Pd was filtered through Celite®, the filtrate was concentrated. The residue was redissolved in DCM (20 mL) and methanol (5 mL), treated with manganese(IV) oxide (561 mg, 6.6 mmol), and stirred at room temperature for 2 hours. Solid was filtered and filtrate was concentrated to give product (0.6 g, 85%).

Provenance & Evidence