Dimethylformamide → HCID 68995057, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1-{2-[4-((2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl){[(1,1-dimethylethyl)oxy]carbonyl}amino)-1-piperidinyl]ethyl}-7-fluoro-2-oxo-1,2-dihydro-4-quinolinyl trifluoromethanesulfonate (0.131 g, 0.19 mmol), zinc cyanide (0.027 g, 0.23 mmol), tris(dibenzylideneacetone)dipalladium (0.017 g, 0.019 mmol) and 1,1′-bis(diphenylphosphino)ferrocene (0.042 g, 0.076 mmol) in DMF (3 ml) was degassed with argon then heated at 90° C. for 18 h. The mixture was allowed to cool then separated between ethyl acetate and brine. The organics were isolated, dried and concentrated. Chromatography (10 g silica SPE gradient elution with ethyl acetate/methanol 0-3%) provided the title compound (0.062 g, 58%) as a yellow oil.

Provenance & Evidence