HCID 86635363, compound → 4-{2-[(3S)-3-(Aminomethyl)-1-piperidinyl]ethyl}-6-(methyloxy)pyrido[2,3-b]pyrazin-3(4H)-one

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Reaction Steps

To a solution of phenylmethyl [((3S)-1-{2-[6-(methyloxy)-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl]ethyl}-3-piperidinyl)methyl]carbamate (0.37 g, 0.83 mmol) in MeOH (20 mL) was added 10% Pd/C (0.10 g). The solution was hydrogenated on a Parr apparatus at 50 PSI for 3 h. The Pd/C catalyst was filtered off, MnO2 (0.22 g, 2.48 mmol) was added, and the solution stirred at ambient temperature for 16 h. The MnO2 was filtered off and the crude material (yellowish oil) was used without further purification (0.26 g, 97% over 2 steps).

Provenance & Evidence