Potassium Carbonate → HCID 86635372, compound

Participants

Reaction Conditions

Reaction Steps

To 3-{4,6-dichloro-2-[(E)-2-phenylethenyl]-5-pyrimidinyl}-1-propanol (275 mg, 0.89 mmol) in DMF (4 mL) was added K2CO3 (0.50 g, 3.6 mmol). The suspension was warmed to 60° C. and allowed to stir 16 h under nitrogen. The reaction was cooled to rt, concentrated to remove most of the DMF and the residue was partitioned between EtOAc and water. The aqueous layer was further extracted with EtOAc (2×), washed with brine, dried over Na2SO4, filtered and concentrated under vacuum. The crude residue was then purified by column chromatography (silica gel) using an EtOAc/hexanes gradient to yield the desired compound as a yellow solid (0.21 g, 88%).

Provenance & Evidence