1-(3-Methoxycarbonyl-2-methylpropanoyl)-L-proline → 1-(4-methoxycarbonyl-2-methylbutanoyl)-L-prolineamide

HRID 65722Notes

Reaction equation

HRID 65722 reaction equation
[CH3:1][O:2][C:3]([CH2:5][CH2:6][CH:7]([CH3:18])[C:8]([N:10]1[CH2:17][CH2:16][CH2:15][C@H:11]1[C:12](O)=[O:13])=[O:9])=[O:4].COC(CC(C)C([N:27]1CCC[C@H]1C(O)=O)=O)=O>>[CH3:1][O:2][C:3]([CH2:5][CH2:6][CH:7]([CH3:18])[C:8]([N:10]1[CH2:17][CH2:16][CH2:15][C@H:11]1[C:12]([NH2:27])=[O:13])=[O:9])=[O:4]

Participants

3

Reactant 2

HCID 538488431-(3-Methoxycarbonyl-2-methylpropanoyl)-L-prolineHCID 541271821-(4-Methoxycarbonyl-2-methylbutanoyl)-L-proline

Product 1

HCID 227996541-(4-methoxycarbonyl-2-methylbutanoyl)-L-prolineamide

Procedure

By substituting the 1-(4-methoxycarbonyl-2-methylbutanoyl)-L-proline of Example 24 for the 1-(3-methoxycarbonyl-2-methylpropanoyl)-L-proline in the procedure of Example 50, 1-(4-methoxycarbonyl-2-methylbutanoyl)-L-prolineamide is obtained.

Sources & evidence

ORD record
ord-d617cbe027bf4e0793b408ce9843be30
Source dataset
uspto-grants-1978_12
Patent number
US04128653

Reaction notes

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